Sunday, 15 March 2015

Serendipity Drug Discovery in Medicinal Chemistry

Serendipity Drug Discovery

Serendipity word refers to a discovery by chance, and it has been explored with a great curiosity. Before 21st  century, early attempts to discover new drugs and new cures were based on intuition and empirical observation, while any successful results were more likely to be the product of fortunate accidents well exemplified by Pencillin discovery by Alexander Flemming, development of Viagra for erectile dysfunction and development of AZT for HIV/AIDS infection,  LSD-25(psychedelic drug), disulfiram (treatment for alcoholism), Meprobamate (anxiolytic drug), Chlordiazepoxide (sedative/hypnotic drug), Chlorpromazine (antipsychotic/ antihistaminic drug), Imipramine (antidepressants), Iproniazid (antidepressant).

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Moreover there are plenty of examples in literature based on serendipity drug discovery,

Serendipity is one of the best leading component to drug discovery, which has given new hope for incurable diseases before 21st century. Although it has certainly played a major role in the discovery of most of the standard psychotropic drugs, anti-infective agents and anticancer drugs.The discovery process admits the identification of the potential findings based on intuition, knowledge and experience.

You can get more information regarding serendipity drug discovery from below given PDFs link

Chance favors the prepared mind Download
Role of serendipity in drug discovery Download
Exploitation of Serendipity in Drug Discovery Download
Serendipity and New Drugs for Infectious Disease Download
Effect of Serendipity in Drug Discovery and Development Download

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